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The goal is to cross-check: to ensure that the disease can be clearly pinpointed to that virus and not to other pathogens that may lurk in samples taken from patients. The first three criteria isolating the virus from diseased hosts; cultivating it in host cells; and proving that the agent passes through a lab filter that traps bacteria, which are bigger than viruses have already been met. Scientists in Rotterdam say they have now successfully carried out the three other Koch tests. These are: inducing the disease in the same or comparable host; re-isolating the pathogen from the sick animals; and detecting a specific response to the virus from the body's immune system. The Osterhaus team used macaque monkeys as a close relative to human species to carry out the trio of experiments. The research could be the final blow to early lab work in the Severe Acute Respiratory Syndrome (SARS) outbreak that suggested another agent was to blame - a paramyxovirus, which is related to the virus that causes mumps and measles. AFP
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